Skin Substitutes-What’s New in 2025? Important CMS Updates and How Revantage Healthcare Can Assist

Navigating the changing rules about skin substitutes can be tough for healthcare providers. New updates for 2025 have been released by the Centers for Medicare and Medicaid Services (CMS). It is essential to remain compliant with these updates. Additionally, efficiency in operations is crucial. At Revantage Healthcare, we focus on managing the details of wound care billing. We help you stay ahead of the curve.

CMS Updates on Skin Substitutes for 2025

Now, these products are known as Cellular and/or Tissue Based Products (CTPs). They have been updated and are part of the Tissue Engineering Products category. The CMS is updating policies for all healthcare services in phases. Here’s what you need to know.

1. Nationwide Local Coverage Determinations (LCDs)

Medicare contractors estimate that new policies will start on February 11, 2025.

They will replace vague comments like “Failure to respond” with clear goals, such as “50% ulcer area reduction.”

They will also increase application limits from 4 to 8. The duration range will extend from 12 to 16 weeks.

Additionally, they will provide guidelines for vascular assessment and list contraindications for appropriate therapies.

2. Modifier Requirements

The Centers for Medicare Services has updated the billing modifier requirements for clarity.

KX Modifier: Used for more than four applications during treatment.

JW Modifier: Records parts of products that were bought but not used, like single-use products.

JZ Modifier: Confirms that no waste happened during the procedure.

3. High-Cost vs Low-Cost Classification

CTPs are classified as high-cost or low-cost for payment reasons. High-cost products use CPT codes 15271–15278. Low-cost products use HCPCS codes C5271–C5278. These classifications help ensure proper payment under the Physician Fee Schedule (PFS) and the Outpatient Prospective Payment System (OPPS). 

How Revantage Healthcare make Wound Care Billing Easy

Wound care billing can be tough, but Revantage Healthcare makes it easy. We provide a complete solution for your billing needs. From claim submissions to compliance, we help you focus on your patients. Wound care billing can be complicated, which is why we work hard to simplify it for you. We handle every part of your billing cycle. This includes submitting claims and ensuring compliance, so you can concentrate on caring for your patients.

Services Include:

Accurate Billing and Coding: Ensuring correct documentation and use of modifiers like -KX, 

JW, and JZ. 

Compliance Expertise: Staying updated on CMS policies, including LCDs and HCPCS 

classifications. 

∙Comprehensive Documentation Support: From wound measurements to justification for 

repeated applications. 

Streamlined Claim Submissions: Managing appeals and follow-ups for timely 

reimbursements. 

Stay Ahead of CMS Changes with Revantage Healthcare

The 2025 updates to skin substitutes billing policies highlight the need for precision and expertise. At 
Revantage Healthcare, we not only simplify the billing process but also ensure you maximize your 
reimbursements while staying compliant. 
Contact us today to learn how we can manage all your wound care billing hassles and let you focus 
on delivering exceptional care. 
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